منابع مشابه
Stem Cells Application in Modeling of Human Genetic Diseases
The use of animal models in modeling of human genetic disease has many advantages. In some cases, however, this method may not be applicable due to some limitations, such as differences in tissue composition, anatomy and physiology of humans and animals. Isogenic human disease models are a population of cells that are selected or engineered to model a specific genetic disease, in vitro. They ar...
متن کاملHuman Genetic Diseases
1Center for Experimental Medicine and Department of Neurology, TheThird Xiangya Hospital, Central South University, Changsha 410013, China 2Clinic and Policlinic for Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, 97080 Wurzburg, Germany 3Division of Neuromuscular Medicine, Davee Department of Neurology and Clinical Neurosciences, Northwestern University Feinberg School o...
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Human prion diseases are fatal neurodegenerative disorders that are characterized by spongiform changes, astrogliosis, and the accumulation of an abnormal prion protein (PrP(Sc)). Approximately 10%-15% of human prion diseases are familial variants that are caused by pathogenic mutations in the prion protein gene (PRNP). Point mutations or the insertions of one or more copies of a 24 bp repeat a...
متن کاملThe spider‘s web Human genetic diseases
Has your research just catapulted you into the vast descriptive world of human genetic diseases? If so, the web offers guidance about research and resources in the field. For a rapid introduction, visit OMIM, Online Mendelian Inheritance in Man Database, which catalogs human genes and genetic disorders. The state-of-the-art site, created by Victor McCusik and colleagues at Johns Hopkins, was de...
متن کاملHuman genetic polymorphisms affecting HIV-1 diseases.
Human immunodeficiency virus type 1 (HIV-1) infection is generally characterized by a long-term, chronic disease course that gradually progresses to acquired immunodeficiency syndrome (AIDS). However, a small fraction of HIV-1-infected individuals remain both clinically and immunologically healthy for 10 years or more after seroconversion. Conversely, the disease of another significant fraction...
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ژورنال
عنوان ژورنال: BioMed Research International
سال: 2015
ISSN: 2314-6133,2314-6141
DOI: 10.1155/2015/315216